Unfortunately this is a known problem and the manufacturer doesn't guarantee Mac use over 10.3.
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Apple® OSX 10.4.x or 10.5.x
Oregon Trail® 5th Edition was designed for use with OS 8.6-10.3.x, so we would be unable to guarantee compatibility with all OS 10.4.x or 10.5.x systems. If Oregon Trail® 5th Edition is used on an OS 10.4.x or 10.5.x system, the sound may skip or distort.
http://support.riverdeep.net/fix.asp?isid=...prog=1294820236
However if you have Windows on your Intel you might be able to get it to work. Some people here did.
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however - i simply installed the game on the windows xp sp2 partition (via boot camp) and it runs perfectly! so, don't run in on your new mac os and you'll be okay.
http://www.amazon.com/review/product/B0009...g#R2F5STGCRTXLN