The way to check this is to look at Activity Monitor and under the Memory tab, look to see what your Page Ins are, vs your Page Outs. If you have a lot of Page Outs (significantly more than your Page Ins, in particular) your computer is short of RAM.
So, have a look in Activity Monitor and report back.
My bet is that you need to feed your Mini some more RAM. You can put up to 8GB in it on 10.6.8 - if you upgrade to 10.7.5 (min) you can put 16GB on it. Your choice. If it was me, I'd get the 16GB, put 8 in, and then wait for Mavericks and install the rest. It's possible you will have to upgrade to 10.8 first, but you may not have to do that - 10.8 can be installed without installing 10.7 first. Is there any reason you're running 10.6.8 instead of 10.8? (I like 10.8, but then I generally keep fairly up to date with my OS, 'cept when it comes to the disaster known as Windows 8.

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And as for your background apps, I'm with Jim. Disable the lot of them, except for TimeMachine. There is absolutely no need to run something like McAfee all the time. Really.
Did you mean "Dashlane" - the password manager, by any chance? There is no app called "Dashland" that I can find.
And get rid of MacKeeper - I don't know how you got hornswoggled into that, but many of us have been warning for years that it's utterly