My son was having the same kind of problem with the Logitech mouse I gave him to use on his new G4. He told me he gave up using it because he couldn't rely on it.
Most likely, it's a driver issue.
I use a cordless WACOM mouse. The only problem it ever has is with sticky menus. Sometimes, the menus will not stay open unless I hold the mouse button down. The next restart I do corrects that.