Nothing backs up automatically, that I know of.
After my experience with my <
2TB Seagate>, all I can say is to be absolutely positive that the drive is absolutely guaranteed to work in an external enclosure. The only other recommendation is to get one with the largest cache and the longest warranty.
The drive, itself, couldn't care less about what I/O interface you use (FW/USB/E-SATA/Pony Express/etc.). That's a function of the enclosure and just about any combination you can think of is available. I will say that FW is generally less popular but more expensive than any of the others (except, maybe E-SATA). I'm sure many will offer specific enclosures to you, I'd only recommend buying from a known quality reputation company. In other words,
not eBay and only after extensive research from an Amazon 'dealer.'