Actually, unless you have a real yen to see Las Vegas, there are some other really interesting things to see in that area that (I think) are more worthwhile. Joshua Tree National Monument, San Jacinto, the Salton Sea (or whatever is left of it these days - rather interesting place!) - all a bit further south than you've mapped.
Another spot I'd work into the itinerary long before I'd go to Las Vegas would be Yosemite. Truly awe-inspiring.
Also, if you are driving down the coast from SF, don't miss the Hearst Castle. It's just north of Morro Bay.
Morro Bay and Pismo Beach are two places worth a stop (we camped at Pismo, I think...eons ago...)
Carmel is worth an afternoon or so - it's charming.
The Monterey Bay Aquarium is worth a stop...
Do stop and see the giant sequoias somewhere along the way...
And consider taking 101 instead of I5. I5 is dead boring. 101 will take a bit longer (about 2 hours longer) but it's much prettier!!
You didn't expect to post your route here and not get a lot of opinions, I hope!
(And I'm not even a Californian - I've just visited there a number of times. We lived in Oregon for 6 years.) If you can let us know what sort of time frame you've got, I'm sure we can all pile in with appropriate suggestions!!