I'm running Leopard 10.5.1 on a MacBook Pro, and Photo Booth seems to work fine. I don't use it, so my only experience is opening it and taking a few snapshots to see if it works after reading your post. I am also using Photoshop CS3 with only a few nits.
My Leopard problems would be funny if not so annoying.
1. One such problem concerns not being able to arouse the computer from the sleep mode. As background, Leopard was put on via a reformat and clean install of everything. I then cloned the internal HD to an external firewire HD. After a week or two of use, the internal HD installation suddenly would not awake from the sleep mode. The computer was for all practical purposes dead. I had to disconnect power and then restart the computer. I put up with this for a day or two and then reformatted the internal HD and cloned the external HD onto the internal HD. Copying a copy of the original back over the original solved the sleep problem. I'll probably never know what caused the conflict.
2. Another such problem involved the failure of the internal HD to boot. A light blue screen appeared with the dreaded flashing question mark. I booted using the install disk and the external HD, but the internal HD was no where to be found. Disk Utility wouldn't recognize the internal HD. I then booted using Restore Disk 1 that came with the computer, holding down D during boot to enter the Apple Hardware Test. I used the extended test. No errors or problems were reported. I called AppleCare and the tech likewise concluded the internal HD had gone sneakers up. A box was ordered to have the computer sent to Houston for repair. The night before the box arrived, and, following a reboot of the external HD, the internal HD icon suddenly appeared out of nowhere. The HD has worked fine since. I don't trust it, but I can't send a working HD to Apple for repair!
3. My current annoyance is the spinning beachball. It will appear at any time and nothing can be done until it is tired of spinning and returns control of the computer.
My next step will be to reformat the internal HD again, and then either reinstall Leopard........or Tiger, depending how I feel at the moment.
Dave